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I didn't see this in the guide, but it bears mentioning that Mildew and Pest Flies can be treated directly using crafted sprays: Mildew Spray <- Empty Spray Can + Milk (can be rotten milk) Insecticide Spray <- Spray Can + Water + Cigarette with one of these can in your main inv, you'll get a 'Treat Problem' option on a crop sick with the appropriate affliction. You need to use enough of the spray to reduce the 'disease counter' to zero. There's a bug where the 'Treat Problem' menu will loose it's contents, placing the can in a placed container (like a crate, not a backpack) and retrieving it fixes this. Devil's Water Fungi has no treatment, better dig it out.