I've had it happen to me twice now,
While playing, my computer I will lose input from mouse & keyboard, not sure why.
I have to turn off my computer to "fix" the problem.
It's either that or watch my character, burn to death, or walk into a horde.
First time, shutting down my computer completely, corrupted the save file.
Second time, I cancelled the shut down during its prevented by programs, did not corrupt game save file.
I do play with mods, and I've tried again.
This time though a jacket did this:
Then, fighting outside, the screen froze, the character continued to repeatedly swing his frying pan, but input only was lost to the game.
trying to reopen, crashed the game. 😪