I've recently noticed a new glitch on my own game that started happening about a week ago, after one of the follow-up updates to Build 40.
My game refuses to save. For the first four or five saves it works normally, but after that it stops. It starts going through the "fade out", then freezes and locks up. It can literally sit for hours and not do anything, so it's not lag. Doing a manual reboot doesn't work well either - all progress is lost, the world map respawns, and in a couple of cases my survivor died of starvation.
It's NOT any of the mods. I tried starting up a brand new game without ANY mods at all and after a few normal saves it "locked" up again, so it's something in the basic game itself. Has anyone else run into anything similar?