I play with a controller quite often and although it's a bit fiddly (took me some time to realize the bumpers moved between loot containers and backpacks, and you'll need a keyboard to access the character window and the health window as well as pause the game) it's typically my preferred method when I'm being a bum and want to connect my pc to my tv. You have to wait until after loading your save to enable the gamepad, otherwise it won't work.